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sitagliptin phosphate intermediates

sitagliptin phosphate

CAS: 654671-78-0;847445-79-8

Molecular Formula: C16H15F6N5O.H3PO4

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sitagliptin phosphate intermediates - Names and Identifiers

Name sitagliptin phosphate
Synonyms sitagpliptin
sitagliptin phosphate
Sitagliptin phosphate
sitagliptin phosphate intermediates
3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazin-7(8H)-yl)-4-(2,4,5-t
(3R)-3-aMino-1-[3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate
7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-phosphate
7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine-phosphate
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
Sitagliptin phosphate 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
CAS 654671-78-0
847445-79-8
EINECS 1806241-263-5
InChI InChI=1/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)/t9-;/m1./s1

sitagliptin phosphate intermediates - Physico-chemical Properties

Molecular FormulaC16H15F6N5O.H3PO4
Molar Mass505.31
Melting Point202-204°C
Boling Point529.9°C at 760 mmHg
Flash Point274.3°C
Solubility Methanol (Slightly, Heated), Water (Sparingly, Sonicated)
Vapor Presure2.59E-11mmHg at 25°C
AppearanceSolid
ColorWhite to Off-White
Storage Condition-20°C Freezer
Physical and Chemical Properties

UseSitagliptin and its intermediates (R & D)
In vitro study Sitagliptin phosphate exhibits a potent inhibitory effect on DPP-4 with IC 50 of 19 nM from Caco-2 cell extracts.Sitagliptin reduces in vitro migration of isolated splenic CD4 T-cells through a pathway involving cAMP/PKA/Rac1 activation.A recent study demonstrates that sitagliptin exerts a novel, direct action in order to stimulate GLP-1 secretion by the intestinal L cell through a DPP-4-independent, protein kinase A- and MEK-ERK1/2-dependent pathway. It therefore reduces the effect of autoimmunity on graft survival.
In vivo study In vivo, the ED 50 value of sitagliptin phosphate for inhibition of plasma DPP-4 activity is calculated to be 2.3 mg/kg 7 hour postdose and 30 mg/kg 24 hour postdose in freely fed Han-Wistar rats.The streptozotocin-induced type 1 diabetes mouse model exhibits elevated DPP-4 levels in the plasma that can be substantially inhibited in mice on an Sitagliptin phosphate diet. This is achieved by a positive effect on the regulation of hyperglycemia, potentially through prolongation of islet graft survival.The plasma clearance and volume of distribution of Sitagliptin phosphate are higher in rats (40-48 mL/min/kg, 7-9 L/kg) than in dogs (9 mL/min/kg, 3 L/kg); and its half-life is shorter in rats,2 hours compared with 4 hours in dogs.
sitagliptin phosphate intermediates
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: Sitagliptin phosphate Visit Supplier Webpage Request for quotation
CAS: 654671-78-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
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Shanghai Amole Biotechnology Co., Ltd.
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Product Name: Sitagliptin phosphate Request for quotation
CAS: 654671-78-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
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Product Name: Sitagliptin phosphate Visit Supplier Webpage Request for quotation
CAS: 654671-78-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
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MedChemExpress (MCE)
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Product Name: MK-0431 phosphate Visit Supplier Webpage Request for quotation
CAS: 654671-78-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
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Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: Sitagliptin Phosphate Visit Supplier Webpage Request for quotation
CAS: 654671-78-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: sitagliptin phosphate Request for quotation
CAS: 654671-78-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple Specifications
Product Name: Sitagliptin phosphate Visit Supplier Webpage Request for quotation
CAS: 654671-78-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
sitagliptin phosphate intermediates
C.I. 26070
Fluorometholone Impurity 9
C. I. Pigment Yellow 34 (77600)
GERANYL PROPIONATE FCC
1.4-DIOXANE SOLUTION 100UG/ML IN METHANOL 5ML
射光蓝浆AG-R
Gadolinium chips
Dihexyl
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